“Non-testing method” refers to any non-experimental method or approach that can be used to provide data for the assessment of chemicals. Non-testing methods include QSAR models and read-across/grouping approaches and can be used to predict in a quantitative or a qualitative manner the physicochemical, biological, i.e. (eco)toxicological, and environmental fate properties of substances from knowledge of their chemical structure and other properties. Both QSARs and read-across/grouping approaches are based on the principle that the properties of substances, including their biological activities, depend on their chemical structure and hence can be predicted from it (similar substances have similar properties).
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